Journal: Epilepsia
Article Title: Single‐neuron correlate of epilepsy‐related cognitive deficits in visual recognition memory in right mesial temporal lobe
doi: 10.1111/epi.17010
Figure Lengend Snippet: Electrode locations, memory recognition task, and behavior. (A) Electrode placement in Montreal Neurological Institute (MNI152) space. Axial (z = −16) plane shows the electrode locations from which we recorded at least one neuron in the amygdala (pink) and the hippocampus (yellow). Each dot is one microelectrode bundle. (B) The memory recognition task consisted of a learning and a recognition block. During learning, 100 unique novel images were shown, each followed by a control question. Following a delay period, a subset of 50 of the images shown during learning were shown intermixed with another set of 50 novel and unique images (100 trials). After each image, subjects were asked to indicate whether they had seen the image and with what confidence on a scale of 1–6. All images shown belonged to one of five visual categories (e.g., vehicles, food, people, houses/buildings, animals, with 20 instances chosen from each category). (C) Accuracy as quantified by area under the curve (AUC) of the behavioral receiver operating characteristic (ROC) curves shown in panel E did not differ significantly between the groups (one‐way analysis of variance [ANOVA], p = .93). (D) Accuracy (percentage correct) as a function of confidence and SOZ group. Accuracy differed as a function of confidence but did not differ significantly between the two groups (2 × 3 ANOVA, high/low vs. SOZ laterality; main effect high vs. low confidence p < 10 −10 , no significant main effect of SOZ group [ p = .99] and no significant interaction [ p = .79]). (E) Average behavioral ROC curves of subjects with right, left, and bilateral mesial temporal lobe SOZs. Gray line indicates chance. (F) Z ‐transformed ROC (zROC) version of the ROC curves shown in C for the three subject groups. Gray line indicates chance. (G) Average zROC slopes across all sessions of each group. Subjects with a left‐sided SOZ had significantly lower zROC slopes compared to those with unilateral right or bilateral SOZs (one‐way ANOVA; 1 × 3 ANOVA, p = .0068; post hoc pairwise comparisons [honestly significant difference], p = .021 and p = .011, respectively). (H) Mean scaled scores for Wechsler Memory Scale verbal paired associates (VPA) and visual reproduction (VR) tests, separately for patients with a right‐sided versus left‐sided SOZ. Patients with a left‐sided SOZ had significantly lower VPA scores compared to those with a right‐sided SOZ (2 × 2 ANOVA, test version immediate/delayed vs. SOZ laterality; main effect of SOZ side, p = .007). Patients with a right‐sided SOZ had significantly lower VR scores compared to those with left‐sided SOZs (2 × 2 ANOVA, test version vs. SOZ laterality; main effect of SOZ side, p = .033). A scaled score of 10 is the mean of the age‐corrected control group (dashed line). Error bars are SEM. * p < .05, ** p ≤ .01, *** p ≤ .001. ns, not significant
Article Snippet: We computed the behavioral receiver operating characteristic (ROC) curve of each session using the ROC MATLAB Toolbox.
Techniques: Blocking Assay, Control, Transformation Assay
MathWorks Inc is a verified supplier 
![Electrode locations, memory recognition task, and behavior. (A) Electrode placement in Montreal Neurological Institute (MNI152) space. Axial (z = −16) plane shows the electrode locations from which we recorded at least one neuron in the amygdala (pink) and the hippocampus (yellow). Each dot is one microelectrode bundle. (B) The memory recognition task consisted of a learning and a recognition block. During learning, 100 unique novel images were shown, each followed by a control question. Following a delay period, a subset of 50 of the images shown during learning were shown intermixed with another set of 50 novel and unique images (100 trials). After each image, subjects were asked to indicate whether they had seen the image and with what confidence on a scale of 1–6. All images shown belonged to one of five visual categories (e.g., vehicles, food, people, houses/buildings, animals, with 20 instances chosen from each category). (C) Accuracy as quantified by area under the curve (AUC) of the <t>behavioral</t> <t>receiver</t> operating characteristic <t>(ROC)</t> curves shown in panel E did not differ significantly between the groups (one‐way analysis of variance [ANOVA], p = .93). (D) Accuracy (percentage correct) as a function of confidence and SOZ group. Accuracy differed as a function of confidence but did not differ significantly between the two groups (2 × 3 ANOVA, high/low vs. SOZ laterality; main effect high vs. low confidence p < 10 −10 , no significant main effect of SOZ group [ p = .99] and no significant interaction [ p = .79]). (E) Average behavioral ROC curves of subjects with right, left, and bilateral mesial temporal lobe SOZs. Gray line indicates chance. (F) Z ‐transformed ROC (zROC) version of the ROC curves shown in C for the three subject groups. Gray line indicates chance. (G) Average zROC slopes across all sessions of each group. Subjects with a left‐sided SOZ had significantly lower zROC slopes compared to those with unilateral right or bilateral SOZs (one‐way ANOVA; 1 × 3 ANOVA, p = .0068; post hoc pairwise comparisons [honestly significant difference], p = .021 and p = .011, respectively). (H) Mean scaled scores for Wechsler Memory Scale verbal paired associates (VPA) and visual reproduction (VR) tests, separately for patients with a right‐sided versus left‐sided SOZ. Patients with a left‐sided SOZ had significantly lower VPA scores compared to those with a right‐sided SOZ (2 × 2 ANOVA, test version immediate/delayed vs. SOZ laterality; main effect of SOZ side, p = .007). Patients with a right‐sided SOZ had significantly lower VR scores compared to those with left‐sided SOZs (2 × 2 ANOVA, test version vs. SOZ laterality; main effect of SOZ side, p = .033). A scaled score of 10 is the mean of the age‐corrected control group (dashed line). Error bars are SEM. * p < .05, ** p ≤ .01, *** p ≤ .001. ns, not significant](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_3636/pmc08403636/pmc08403636__EPI-62-2082-g001.jpg)